Albion were beaten 0-2 by Wolves at The Hawthorns in an FA Cup fourth-round match on Sunday.
Wanderers advanced through to the last-16 after goals either side of half-time by Pedro Neto and Matheus Cunha.
Carlos Corberán’s team are back in Sky Bet Championship action next Saturday, when they host Birmingham City.
The boss made two changes for the derby clash, giving Josh Griffiths a start in goal and replacing the injured Adam Reach with Nathaniel Chalobah.
And his team began brightly - Brandon Thomas-Asante and Jed Wallace both seeing headers saved by Jose Sa within the opening 10 minutes, before BTA had a poke diverted wide.
Arguably the best chance fell to John Swift, the midfielder found deep inside the box following great Wallace play, but his skilful effort was well blocked by Craig Dawson.
It was Wolves, though, who went ahead. They broke quickly from an Albion corner, and Neto squeezed home a low finish to ensure they took a 0-1 lead into half-time.
Swift stung Sa’s hands and a Thomas-Asante penalty shout was waved away as Albion attempted a comeback early in the second period.
The teams then exchanged chances as they searched for that all-important next goal - Jeanricner Bellegarde curling narrowly wide and Thomas-Asante firing over.
But, 12 minutes from time, Wolves were the ones to eventually find the net again, Cunha’s low effort beating Griffiths and doubling their advantage.
Albion: Griffiths; Furlong, Bartley (Taylor 78), Kipre (Pieters 78), Townsend (Pipa 78); Chalobah (Fellows 67), Yokuslu, Mowatt; Wallace, Thomas-Asante, Swift.
Substitutes: Palmer, Hall, Whitwell, Heard, Malcolm.